![]() I have the same type of shades from Revolution – C5 is my every day shade and C6 is my highlighting shade. From Tarte I use Light-Medium for spot concealing and every day under eye concealing, then I use Light for highlighting when I’m going full glam. I have two shades each of the Tarte and Revolution concealers – and they are all very comparable. Of the two, I never need to set the Tarte concealer with powder as it doesn’t really crease on me but I usually set the Revolution one as it can crease. I find the Revolution one a little less thick and less drying. I would say the Tarte concealer is a lot thicker so it’s easy to go overboard and end up looking a bit dry. I’ve mentioned my under eye dark circles a number of times and I know I can always rely on both concealers to cover them up better than most others. ![]() Another thing that the Revolution one does, and I’ll struggle to explain this so bear with me, is that when you put the applicator back in the tube, if you don’t twist it to close it straight away it pops back up and I always end up getting concealer all over my fingers! Does that make sense? It irks me.īoth concealers are praised for being super full coverage and I would definitely agree with that. The applicator is also bigger than most concealers but also can get messy just like the Tarte one. The Revolution packaging is pretty similar, but is quite a bit shorter. One thing I’ll say about the packaging is that it can get messy! The applicator picks up a lot of product which doesn’t get scraped off as it’s pulled out of the tube. It has definitely inspired more brands launching concealer since then. It comes in a thicker tube with a chunky doe foot applicator. The Tarte packaging was quite unusual for a concealer. ![]() The supersize one retails for just £7 and is available here. Revolution have just launched a supersized version of their concealer which contains over 3 times more product (13ml) so I will definitely be buying that one next time I need to repurchase. I find I need a lot less of the Tarte one so it has lasted me absolutely ages, however with daily use of the Revolution one I have repurchased several times over. There is a big difference in quantities – you get 10ml of product in the Tarte tube and just 4ml in the Revolution one. I find that in-store most shades are either sold out or have been opened (why are Superdrug shoppers so annoying?!) so now that I know my shades, I buy online. You can also buy direct from the Revolution Beauty website here. ![]() The Revolution Conceal and Define is a lot more accessible for us here in the UK, you can buy it from Superdrug in-store and online here and it costs just £4. It’s not available on its own from QVC, it comes with the Tarte beauty sponge – which is a good sponge to be fair. The Tarte Shape Tape is available from QVC here and costs £28.02 plus £3.95 postage. They have also launched more shades since bringing the total up to 25. Upon release, Tarte launched 11 shades which were heavily weighted towards lighter skin tones (and then launched the foundation which had all sorts of uproar for the same reason), whereas Revolution released a more acceptable 18 which were varied and widely inclusive. Very quickly it was hailed as Tarte Shape Tape’s younger, cheaper sibling. Then probably a year later, Revolution (official dupe masters) released the Conceal and Define Concealer. It didn’t release in the UK straight away but then QVC graced us with it a few months later. I may be a bit late with this post as this dupe has been talked about for a while now but I’m sure I’ve still got some readers who’d like to see a side by side comparison and review of two of the current most talked about concealers, so here it is.Ĭast your mind back to 2016 when the Tarte Shape Tape concealer was released and the beauty community went crazy for it.
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Here are our favorite free virtual escape room games: 1. When you want to take part in an online escape room but don’t have budget to allocate towards paying for more elaborate ones, there are a ton of great, simple free versions available. Price: Starting at $12 per person 9 Free Virtual Escape Rooms for Work You’ll have to work together to uncover clues and solve complex challenges to lift the ancient curse. In this virtual escape room experience, your team will be transported into a pyramid cursed by a restless mummy. Centered around solving a mysterious murder, this escape room includes multiple different rooms, each with its own unique theme. Looking for a virtual escape room with a great story and some fun challenges? Then this is a perfect fit for your team. Its themes include engineering, coding, photography, and reading, making it perfect for students and teachers or anyone who simply likes to test their smarts. ![]() With its 3D graphics, this escape room offers a video game feel to add a new level of engagement.įor teams that want to take a more education-based approach to their virtual escape room team building activity, Brain Chase is a great bet. If you’re looking for a digital escape room with some added production value, check out Cofundrum. Unlike the question-and-answer format of many other online escape rooms, Trapped in the Web is all about using the internet to track down clues in text-based adventures that utilize video and picture elements. Channel your inner Sherlock Holmes for themed escape rooms like The Bell Witch Hauntings, Nancy Drew, Moriarty’s Parlor, and more. These virtual escape room games are perfect for people who absolutely love a good mystery or problem solving team building activities. While many online escape rooms focus on heists, curses, and spies, Paruzal Games offers puzzle-based challenges with themes focused on things like pizza, rock ‘n roll, golf, coffee, and movies. Price: Custom digital escape rooms start at $750 plus $25 per person 7. With its app-based escape rooms, they’re able to tailor questions and clues to fit your industry or brand. If you’re looking for a custom-built virtual escape room challenge, Wildly Different can accommodate. ![]() There is no shortage of virtual escape room options available from YouEscape, with themes ranging from music to constellations, bomb-diffusing, and solving murders. ![]() This mythical challenge takes place in an enchanted forest accessible via Zoom, where you and your team will need to solve puzzles and escape a witch’s curse. A digital dashboard also keeps track of clues and allows you to do a 360-degree scan of the room. The Escape Game Remote Adventuresįor remote teams who can’t get together in person, The Escape Game Remote Adventures offers 60-minute virtually-hosted challenges with themes like Prison Break, Gold Rush, and More. As a perfect companion to any escape room box activity, they’ll love unpacking delicious snacks during the course of your event. Tip! Send out surprise at-home snack boxes to give your team all the energy they need to escape your room and live happily ever after. ![]() There are a ton of options available, including a race to stop a nuclear bomb, a getaway from a runaway train, or a daring prison break. Much like the last digital escape room we shared, Escape Experience is a hybrid activity hosted by an on-site guide. Price: Virtually-hosted starting at $11 per person This virtual activity is based on our popular in-person Corporate Escape Rooms, Jewel Heist and The Mummy’s Curse. But be quick! The clock is ticking before the stolen score is gone forever. In this virtually-hosted escape room activity, you and your team will need to uncover hidden clues and solve a series of brain-boggling challenges that require collaboration, creative problem-solving, and outside-the-box thinking. There’s been a robbery! Someone has masterminded a heist to steal a priceless collection of precious jewels, and it’s up to you and your team to recover them before time runs out. Here are some of our favorite paid virtual escape rooms available on the internet. If you’ve got a little bit of budget to invest in an online escape room for yourself and your colleagues, the options are pretty much limitless. 4 Virtual Escape Rooms for Friend Groups.3. The Assassination of Abraham Lincoln. ![]() Therefore, we investigated the cytotoxic effects of CPT-11 in promyelocytic leukemia HL- 60 cells and in vivo and tumor growth in a leukemia xenograft model. Irinotecan HCl (CPT-11) is an anticancer prodrug, but there is no available information addressing CPT-11-inhibited leukemia cells in in vitro and in vivo studies. ![]() All rights reserved.Īntitumor effects with apoptotic death in human promyelocytic leukemia HL- 60 cells and suppression of leukemia xenograft tumor growth by irinotecan HCl.Ĭhen, Yung-Liang Chueh, Fu-Shin Yang, Jai-Sing Hsueh, Shu-Ching Lu, Chi-Cheng Chiang, Jo-Hua Lee, Ching-Sung Lu, Hsu-Feng Chung, Jing-Gung Collectively, gossypol treatment can reduce phosphorylation of Bcl-2 at serine 70 in leukemia HL- 60 cells and gossypol may be a promising therapeutical candidate for leukemia patients especially expressing phosphorylated Bcl-2 at Ser70. In addition, pre-treatment of PDBu partially prevented gossypol-induced apoptosis in HL- 60 cells. This reduction was found to be not only in both dose- and time-dependent fashion but also obviated by phorbol l2,13-dibutyrate (PDBu), an activator of protein kinase C (PKC). However, phosphorylation of Bcl-2 at serine 70 (phospho S70) was strikingly down-regulated in gossypol-exposed cells. Bcl-2/Bcl-xL/Mcl-1 protein levels were slightly reduced and phosphorylation of Bcl-2 at threonine 56 (phospho T56) was not altered. We found that gossypol treatment inhibited cell growth and induced apoptosis in HL- 60 cells. Here we investigate the alterations of Bcl-2/Bcl-xL/Mcl-1 protein levels and Bcl-2 phosphorylation in gossypol-induced apoptosis in human leukemia HL- 60 cells. However, the molecular mechanisms underlying apoptosis induction by gossypol in malignant cells have not been completely enunciated. ![]() Gossypol is an attractive therapeutic anti-tumor agent as an apoptosis inducer and is being evaluated in preclinical tests. Huang, Li-heng Hu, Jia-qi Tao, Wei-qun Li, Yuan-hong Li, Guan-ming Xie, Pei-yi Liu, Xiao-shan Jiang, Jikai Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL- 60 cells. These data suggest that morphinone induces non-apoptotic cell death in HL- 60 cells. The autophagy inhibitor 3-methyladenine (0.3-10 mM) slightly inhibited the morphinone-induced cytotoxicity, when corrected for its own cytotoxicity. Electron microscopy demonstrated that morphinone induced mitochondrial shrinkage, vacuolization and production of autophagosome and the loss of cell surface microvilli, without destruction of cell surface and nuclear membranes in the HL- 60 cells. Morphinone dose-dependently activated caspase-3 in both HL- 60 and HSC-2 cell lines, but to a much lesser extent than actinomycin D. Morphinone did not activate caspase-8 or -9 in these cells. Morphinone also induced an almost undetectable level of internucleosomal DNA fragmentation in the HL- 60 cells. Morphinone showed slightly higher cytotoxic activity against human tumor cell lines (oral squamous cell carcinoma HSC-2, HSC-3, HSC-4, NA, Ca9-22, promyelocytic leukemia HL- 60, cervical carcinoma HeLa) than against normal oral human cells (gingival fibroblast HGF, pulp cells HPC, periodontal ligament fibroblast HPLF). Whether, morphinone, an oxidative metabolite of morphine, also induced a similar type of cell death in HL- 60 cells was investigated. Takeuchi, Risa Hoshijima, Hiroshi Nagasaka, Hiroshi Chowdhury, Shahead Ali Kikuchi, Hirotaka Kanda, Yumiko Kunii, Shiro Kawase, Masami Sakagami, HiroshiĪs previously suggested, codeinone (oxidation product of codeine) induces non-apoptotic cell death, characterized by marginal caspase activation and the lack of DNA fragmentation in HL- 60 human promyelocytic leukemia cells, which was inhibited by N-acetyl-L-cysteine. Induction of non-apoptotic cell death by morphinone in human promyelocytic leukemia HL- 60 cells. ![]() This cheat sheet covers the basics of Microsoft Edge, including how to set up the browser and optimize and use key features. In the blank field, type your new home button page (i.e. Microsoft Edge is the default browser for Windows 10.Do the same for each specific file type: HTTP, HTTPS. At the top, make sure “ Show the home button” is enabled. Click the name of the current default browser for HTTPS and change it to your chosen browser and click OK.Scroll down to “ Advanced Settings” (almost at the very end of the menu list). ![]() In the Customize toolbar section, locate the switch labeled Show Home and click it to turn it on. On the Settings screen, navigate to the Appearance section. In the menu that appears, select Settings. So, here’s finally a good step-by-step guide on how to add the home button and change the homepage : To change your default search engine in Microsoft Edge: Perform a search in the address bar using the search engine you want to set as your default. First, open Edge and click the ellipses button (three horizontal dots) in the upper-right corner of the window. But the start page will only come into the picture when you open Edge or when you add a new tab. Yes, there are a lot of examples of how to change the start page. Also, many people are missing the home button in their menu. You can check for the version or update the browser in Settings > About Microsoft Edge.Wandering on the internet, I found out there’s no good explanation on how to change the homepage of Microsoft Edge. So, you must be running Edge version 86 or newer to change the new tab page background. To revert, repeat steps 1-3 and click ‘Remove' or ‘Image of the Day.'įor starters, the custom image background feature was introduced with Edge 86. If you want, you can always change the image or go back to the default image. ![]() The selected image will now be set as the new tab background in Edge. Tap Upload and select the image you want to set as the New Tab background.Then, click on Your own image under the background.Here, select Custom under page layout.Click the Settings button given at the top-right.Click the 3 dots (also known as 'More') to reveal a menu, then choose the Settings option. If the icon isn’t on the extensions bar, click the Menu icon, select the extension, and then click on Extensions options to open up the settings. At the top right of the Edge screen you will see 3 dots just underneath the X (close button). To change the home page: Choose Microsoft Edge from the Microsoft Edge active toolbar on your Mac. Click GET POLICY FILES to download our policy templates. The Microsoft Edge home page is the one that shows up whenever you click on the Home icon. On the Build dropdown list, select any 81 build or later. On the Channel/Version dropdown list, select any channel with version 81 or later. To get the policy manifest: Go to the Microsoft Edge Enterprise landing page. You can go straight to your home page from the Settings page by clicking the house-shaped 'Home' button in the upper-left side of the page. Open the New Tab page in Microsoft Edge. Click Start and type in 'edge' (no quotes) and wait for the Microsoft Edge icon to appear, then left click it to launch it. Get the policy manifest for a specific version of Microsoft Edge. Type in whatever website you want to use for your Firefox home page, then press Enter.Steps to Set a Custom Picture as New Tab Background in Edge But before we start, make sure that you are using the ‘Informational' or Inspirational' page layout. The default homepage for Microsoft Edge is the New tab page, which means that pressing the Home button opens a new tab. If you're someone who likes customizing the browsing experience, you can follow the step-by-step process below to change the new tab image. ![]() They are often enjoyed as a sweet snack, used as a treat for kids, or included in candy assortments and party favors. Now & Later candies have found their way into pop culture, making appearances in movies, TV shows, and various forms of media. The candy's distinctive packaging, with vibrant colors and bold lettering, adds to its appeal and recognizability. Now & Later has remained a popular choice among candy enthusiasts due to its long-lasting flavor, chewy texture, and variety of fruity options. Today, Now & Later is still produced and distributed by the Hershey Company. Beatrice Foods sold the brand to the Leaf Candy Company, which was later acquired by the Hershey Company in 1996. Over the years, Now & Later has undergone various ownership changes. Each candy is individually wrapped, making it convenient for sharing or enjoying on-the-go. Now & Later candies come in a variety of flavors, including strawberry, cherry, grape, banana, and apple. The candy's name also signifies the experience of savoring the taste both immediately ("now") and over time ("later"). However, as it warms up and softens in the mouth, it becomes easier to chew and enjoy the fruity flavors. When initially consumed, the candy is firm and requires some chewing. The name "Now & Later" was chosen to highlight the candy's unique texture. The candy was created as a variation of the popular taffy-like candy known as square caramels. Now & Later was first introduced in 1962 by the Phoenix Candy Company, which later became a subsidiary of the Beatrice Foods Company. Let's delve into the history behind this chewy and flavorful treat. 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VirtualDJ PRO for Windows 10 - Full description ![]() Dragon Dictate for Mac offers special upgrade pricing for current Dragon Dictate for Mac and MacSpeech Scribe registered users.1 Focus Medical Software Offers Specialized Sales and Support for Dragon® Dictate Medical for Mac Version 4 Popular Speech Recognition Technology Unveils All-New Version, Now Availableġ Focus Medical Software is pleased to offer Dragon® Dictate Medical for Mac Version 4, recently released by Nuance Communications. 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